Fenbendazole myeloma

The known toxicity profile and selective activity against myeloma cells provide the rationale for considering nocodazole/fenbendazole as future treatment for multiple myeloma. As a long-term multiple myeloma survivor and MM coach I'm often asked about non-conventional (not FDA approved) multiple myeloma therapy Albendazole, fenbendazole, and nocodazole significantly inhibited multiple myeloma cell proliferation with an IC 50 value of 25 to 94 nmol/L for U266 multiple myeloma cells and an IC 50 value of 63 to 380 nmol/L for H929 multiple myeloma cells Flubendazole induced cell death in leukemia and myeloma cell lines and primary patient samples at nanomolar concentrations. Moreover, it delayed tumor growth in leukemia and myeloma xenografts without evidence of toxicity. Mechanistically, flubendazole inhibited tubulin polymerization by binding tubulin at a site distinct from vinblastine Fenbendazole, Mebendazole and related drugs are anthelmintics, i.e. antiparasitic drugs that expel parasitic worms and other parasites living in the body. Fenbendazole is approved for treating a range of animals including cats and dogs, Mebendazole for use in humans Background: Fenbendazole (FBZ) is a cheap and readily available anti-parasitic commonly used in veterinary medicine. FBZ belongs to the benzimidazole drug class which destabilize microtubules through a mechanism similar to the anti-oncogenic vinca alkaloids

Fenbendazole, an over-the-counter dewormer drug used often to treat rodent pinworm infections in dogs, is fast becoming a successful anticancer drug treatment in many late-stage cancers in humans due to the experience of Joe Tippens over at MyCancerStory.rocks Fenbendazole, is a drug used typically not for humans like Mebendazole, but for animals (including fish, birds and mammals). In this case, it is used to kill worms such as roundworms, hookworms, whipworms, and some tapeworms. Fenbendazole is found under various brand names such as Panacur or Safe-Guard The Fenbendazole is about $10 a week with the vitamin E and Theracurmin making up the rest. The Fenbendazole is branded as Panacur C and comes with three packs of powder that you simply tear open and [] Posts navigation. Older posts. Create a free website or blog at WordPress.com Fenbendazole & Cancer My Experience with Panacur C and Colon Cancer. Written by dtcdirector May 14, 2020. Update. Hello Everyone. I am sorry that I have not written in awhile, but life took over and I have had some good and bad experiences that I will fill you in on. As many of you have read, I had stopped taking fenben sometime ago, but it has.

Multiple Myeloma Therapy- Fenbendazole aka The Vet Cure

  1. How to use Fenbendazole (Bulk) 100 % Powder. Consult your pharmacist or physician. Consult your pharmacist or physician. Call your doctor for medical advice about side effects. You may report side.
  2. fenbendazole has been around for decades and they have given much larger doses than Joe tippens took to humans in study for any adverse effect. what is a tip off that it is actually a strong anti-cancer agent for the tubule destabilization is that the cousin (menbendazole) was bought by another company not that long ago and the price for a.
  3. Fenbendazole and other benzimidazole drugs certainly have some proven anti-cancer action. This action is best described as inhibiting the progression of cancer and even killing some difficult-to-treat cancer types including melanoma, lymphoma, lung cancer, prostate cancer, and glioblastoma
  4. The weekly injection of Velcade isn't so bad. I take one dose of anti-nausea beforehand and haven't needed anymore anti-nausea drugs afterwards so far. I end up with a little localised bruising. The drug kicks in fully after about 36 hoursfunny sensations, aches, pains (all bearable) in my bonesI visualise Myeloma shrivelling and.

Leukemia and myeloma cell lines were treated with increasing concentrations of flubendazole. Seventy-two hours after incubation, cell growth and viability were measured by the MTS assay. Flubendazole reduced cell viability with an 50% inhibitory concentration (IC 50 ) less than 1Ī¼M in 8 of 8 myeloma and 4 of 6 leukemia cell lines, including. Fenbendazole - a low cost, effortlessly synthesized anthelmintic medicine used to treat numerous kinds of flatworms, roundworms and hookworms, in livestock. The most recent occasions have demonstrated that fenbendazole might be regarded as an anticancer prescription drug. This particular compound does not dissolve in water. It is usually given as a non-hygroscopic white and viscous [ Multiple myeloma is a disease of plasma cells, white blood cells found in the bone marrow that, as key parts of the immune system, make antibodies. Uncontrolled growth of plasma cells can lead to anemia, fractures and bone pain, reduce the number of normal blood cells and churn out large amounts of abnormal proteins that can damage the kidneys. It can occur in myeloma patients as bone disease causes too much calcium to be released from the affected bones. Kidney damage - Kidney damage can occur in myeloma patients for a variety of reasons. The abnormal protein produced by myeloma cells can damage the kidneys, as can some of the other complications, such as hypercalcemia

October 25, 2019 , by NCI Staff. Increasing the expression of the BCMA protein on the surface of multiple myeloma cells may improve the efficacy of BCMA-targeted CAR T-cell therapy, results from a new study suggest. Credit: National Cancer Institute. The relatively new type of cancer treatment know as CAR T-cell therapy is already being used to. Later the drug was brought back to treat and prevent some forms of leprosy and to treat multiple myeloma, a bone marrow cancer. He also cited the antibiotic erythromycin, which can cause diarrhea.. My journey surviving pancreatic cancer using Joe Tippens protocol, fenbendazole, prayers, and a very positive attitude.Diagnosed in October of 2018 - Stage 1.. Fenbendazole is a cheap, easily synthesized anthelmintic medication effective against many types of hookworms, roundworms and flatworms in animals. The latest events have shown that fenbendazole may be considered an anti-cancer medication. This chemical molecule is practically insoluble in water and often is provided as the non-hygroscopic white or creamy powder

Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell typically responsible for producing antibodies We tested the direct effects of benzimidazoles on human multiple myeloma cell proliferation and cell death induction. Albendazole, fenbendazole, and nocodazole significantly inhibited multiple myeloma cell proliferation with an IC 50 value of 25 to 94 nmol/L for U266 multiple myeloma cells and an IC 50 value of 63 to 380 nmol/L for H929. Fenbendazole (often abbreviated FBZ) is used in both large and small animals. In dogs, it is useful against roundworms, hookworms, and the more difficult to treat whipworms. Multiple Myeloma in Dogs and Cats. Mushroom Poisoning in Dogs and Cats. Muzzle Folliculitis and Furunculosis (Chin Acne, Muzzle Acne) in Dogs Her multiple myeloma then stabilised with a paraprotein level falling to 13 g/L. Over the following 5 years she only took curcumin and her myeloma has continued to remain stable, her blood counts are in the normal range, and there has been minimal fluctuation in her paraprotein levels. In effect this is a cure

Targeting the Microtubular Network as a New Antimyeloma

  1. thic drug belonging to the class of benzimidazoles, approved by the FDA for getting rid of worm infections of many kinds- hookworms, whipworms, roundworms, and pinworms and echinococcosis (hydatid disease). Albendazole (ABZ) is a closely related anti-hel
  2. Fenbendazole is a more effective cytotoxic agent as compared with cisplatin and taxol function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 2010; 115:4824-4833. [Google Scholar] 31
  3. tics and fungicides on the basis of their antimicrotu-bule activity (10) and have been reported to elici
  4. Fenbendazole was previously reported to interfere with one lymphoma model in 2008, 23 after we had already noted problems with fenbendazole disrupting brain tumor engraftment. We pursued this finding by evaluating whether the 2 most widely used human approved benzimidazoles showed efficacy against glioblastoma models
  5. E (800mg per day, 7 days a week). Gamma E by Life Extension or Perfect E are good choices. Bio-Available Curcu
  6. Fenbendazole is still being manufactured in the US and is the go to drug for animals. Fenbendazole does work on Beaver Fever or Giardia as I had a Vet suggest I give it to a cat he thought had Giardia. I use it once a month on all my dogs and cats for parasite control. I would vote against it's ability to kill fungus

Stories and Psychology Tips from a Clinical Psychologist with Multiple Myeloma. (Blood and Bone Cancer) Alive and Kicking. Feb. 26. 2021. by Janine 8 comments Dexamethazone, Dog Wormer, Drugs, Fenbendazole, House Music, Myeloma, Repurposed, Steroid, Thalidomide, Velcade. I've been dying to go so as I'm dying, I'm going. Dec. 19. 2019. I've NEVER read a multiple myeloma success story! I'm SO impressed with your faith, drive and determination! You are an inspiration!ķ ½ķ¹ķ ¼ķæ»ā™„ļø. I now have stage 2B breast cancer and am fighting it with prayer, Fenbendazole, exercise and building my immune system w/diet while lightening the toxic load on my body Multiple myeloma is the second most prevalent blood cancer after non-Hodgkin's lymphoma, according to the FDA. Some 45,000 people in the U.S. alone have multiple myeloma, and an estimated 14,600 new cases are diagnosed each year. Velcade is the first in a new class of anti-cancer agents known as proteasome inhibitors Fenbendazole is a cheap, easily synthesized anthelmintic medication effective against many types of hookworms, roundworms and flatworms in animals. (CLL), non-Hodgkin's lymphoma and multiple myeloma) also belongs to the same class (benzimidazole) of compounds, but their anticancer mechanism differs from anthelmintic benzimidazoles'..

Myeloma - Pathophysiology and Preclinical Studies excluding Therapy. Nocodazole Induces Myeloma Cell Death by Disrupting the Microtubular Network, Resulting in G2/M Arrest. Author links open overlay panel Rentian Feng PhD 1, * Jorge A Rios MD 1, * Markus. An anticancer drug using the mechanism of fenbendazole was first made in the 1990s as a first-generation cytotoxic anticancer drug, and is already used for cancer patients Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths Fenbendazole is sold under several different brand names, one of which is Panacur C from Merck, which is a canine dewormer. It comes in the form of granules containing 22.2 percent Fenbendazole. In other words, each gram of the product has 222 milligrams of active ingredient

The antihelmintic flubendazole inhibits microtubule

Fenbendazole binds Ī²-tubulin, inhibits microtubule formations, and thereby blocks mitosis in nematodes (Friedman and Platzer, 1978). Fenbendazole has greater sensitivity for nematode as compared to mammalian tubulin, and is safely administered to mammals at therapeutic doses. However, it may also influence mammalian cells The development of multidrug resistance (MDR) is detrimental to successful chemotherapy in various cancers [1,2,3].There are various mechanisms underlying the resistance to chemotherapeutic drugs in cancer cells [3,4,5,6].A major mechanism of resistance is the overexpression of ATP-binding cassette (ABC) transporters, which could efflux the chemotherapeutic agents out of cells [7,8,9] Fenbendazole, [5-(phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester, is widely used to treat pinworms, other helminthes, and a variety of parasitic infections in laboratory animals, livestock, companion animals, and people (1-3).We became interested in fenbendazole when our university veterinarians recommended that all experimental rodents, including uninfected colonies such as. A comprehensive review of Hyperbaric Oxygen Therapy in cancer treatment. Hyperbaric Oxygen Therapy, HBO, or HBOT, or HBO2T, can be an important part of a complementary and integrative cancer treatment programme (Chris Woollams). It can increase blood oxygen levels quickly to 100 per cent, it can presensitise cancer cells so that more are killed by chemotherapy and radiotherapy, it can also. Patients with relapsed multiple myeloma (MM) previously treated with bortezomib and lenalidomide often fail to respond to further therapies. To identify potential new treatment approaches for MM, we used Luminex technology to screen a library of 1,120 compounds provided by the Multiple Myeloma Research Foundation

Surviving stage 4 cancer with Fenbendazole cancer cur

Dr. Wojciechowski: Yeah, and they noticed that the ones that got the fenbendazole, the tumors wouldn't grow. So then they started testing, you know, giving some mice fenbendazole, and some mice didn't get fenbenzadole, and they found that there was a real signal there. The fenbendazole seemed to be helping to kill these tumors in these mice Diagnosed with terminal lung cancer, Joe was told he had about 3 months to live. A veterinarian friend of his in western Oklahoma called him and told him about a cancer research experiment he had learned about in which a dog-deworming medicine had cured cancer in the experimental mice and when the researcher developed cancer, she used the same medicine on herself and her glioblastoma was.

154) Duan, Qiwen, Yanfeng Liu, and Sara Rockwell. Fenbendazole as a potential anticancer drug. Anticancer research 33.2 (2013): 355-362. 155) Aycock-Williams, Ari N., et al. Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells. J Cancer Res Exp Oncol 3.9 (2011): 115-121 Fenbendazole (often abbreviated FBZ) is used in both large and small animals. In dogs, it is useful against roundworms, hookworms, and the more difficult to treat whipworms. Multiple Myeloma in Dogs and Cats. Mushroom Poisoning in Dogs and Cats. Myeloma-Related Disorders in Cats. Nasal Pharyngeal Polyps in Cats A more specific herbal supplement-drug interaction is that of green tea extract (EGCG) and Velcade (bortezomib), a chemotherapeutic agent used to treat multiple myeloma, a type of blood cancer. EGCG has been shown to reduce the anti-tumor effects of bortezomib, she said effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast cancer, colorectal cancer and For example dogs treated with fenbendazole with a single dose with a different range of 25 to 100 mg/kg had simi-lar AUC level (16). Another study has found that the max Alcohol can actually interfere with healthy production of white blood cells, red blood cells, and platelets in your bone marrow. For patients with blood and marrow cancers, such as leukemia, lymphoma, and myeloma, bone marrow function may already be strained as a result of their disease. 1 ļ»æ If you add that to the bone marrow damage that.

Fenbendazole Cancer Protocol - Step By Step Guide (2021

Prior to my mulĀ­tiĀ­ple myeloma diagĀ­nosis, I susĀ­pect that the most physically painful chalĀ­lenge I faced was a broken jaw. Emotionally painful, no doubt about it, was the death of my father. Mentally taxing, I suppose, is running my own busiĀ­ness. Read the full story Ā If you have a blood-related cancer like multiple myeloma, your bone marrow may not be able to make enough blood cells.This is called myelosuppression or bone marrow suppression. It can also be a. Stem cell transplant for multiple myeloma life expectancy - multiple myeloma stem cell transplant survival rate - stem cell transplant for multiple myeloma - If there is a disease which most clearly demonstrates the recent improvements in the treatment of cancer, is multiple myeloma. Advances in biotechnology have allowed scientists to identify several genetic and chromosomal abnormalities. Next, the mode-of-action of fenbendazole on HL60 cells was investigated by cellular imaging in 1, 3, 5 and 7 days after treatment with three different concentrations (0.1, 0.2 and 0.5 ĀµM) of.

The diagnosis: chronic lymphocytic leukemia (CLL), a cancer of the lymphocytes, or B cells, that begins in the bone marrow and migrates to the blood and sometimes to lymph nodes. CLL strikes more than 20,000 people in the United States each year, according to the American Cancer Society, and affects more men than women Jennifer's Clinical Trial Story. Jennifer Carrieri was shocked when she found out she had multiple myeloma. The young mother of two was put on a clinical trial with Memorial Sloan Kettering oncologist Pamela Drullinsky and received a stem cell transplant in October. Now she's healthy, back to work, and looking forward to celebrating her 40th. Multiple myeloma survivor grateful CAR T cell therapy clinical trial gives her another option. Two-time cancer survivor: MD Anderson is helping me beat the odds. Anal cancer survivor: Go directly to MD Anderson. View more View less. Video Gallery . How clinical trials advance innovative cancer care

Is Fenbendazole The 2021 Anti-Cancer Drug Treatment For

A Drug Made for Animals and Taken by Humans to Treat

Fenbendazole & Cancer - My Experience with Panacur C and

Update - Fenbendazole & Cance

The medication, fenbendazole, is an anti-worm compound used to treat hookworms, roundworms and other gut parasites in animals, primarily dogs.. Budwig Protocol is the best alternative treatment for cancer. It acts upon the prime cause of the cancer. Prime cause of the cancer is lack of oxygen in the cells, as discovered by Dr Otto Warburg in 1931 and was awarded Noble Prize. He proposed that sulfur containing protein (found in cheese) and some unknown fat is required to attract oxygen. My father was diagnosed with advanced multiple myeloma. He tried oral chem and lasted 21 days. He felt awful while taking it, had 2 TIA's and got gout. He decided he didn't want to continue. I had immediately got him taking cannabis oil with high cbd. He was also taking high doses of vitamin D and tumeric. He also had vitamin C infusions Bloodroot and Cancer. Bloodroot-containing products sold as a cure for cancer can be highly toxic and result in disfigurement. Bloodroot ( Sanguinaria canadensis) is an herbaceous plant native to. Low blood levels of coenzyme Q10 have been found in patients with myeloma, lymphoma, and cancers of the breast, lung, prostate, pancreas, colon, kidney, head and neck. Most of the original research on CoQ10 centered on the treatment of heart failure, but two older journal articles highlight it's potential in combating cancer and maintaining a.

Fenbendazole (Bulk): Uses, Side Effects, Interactions

Testimonials of healing cancer naturally. The survivors in this post used an variety of healing dietary protocols including raw vegan, Gerson, ketogenic, metabolic, and macrobiotic, along with the implementation of various detoxifying protocols, supplementation, herbal remedies, essential oils, cannabis oil, Budwig protocol, essiac tea, laetrile, black salve, antineoplaston therapy, etc Multiple myeloma often weakens the bones and may cause fractures. Bones in the spine can collapse and damage the spinal cord, which is a collection of nerves in the back Wonder Drug. by Jeffrey Dach MD. The 2015 Nobel Prize in Medicine went for discovery of Ivermectin, an astonishingly safe FDA approved anti-helminthic drug. 200 million people take the drug globally for prevention or treatment of parasitic disease. Dr Sharmeen at the University of Toronto screened a library of 100 drugs for activity.

Tippens said he received a tip from a veterinarian who suggested he try a dog dewormer drug called fenbendazole, which was believed to display cancer-fighting properties, according to cell studies BRAF V600E is an inclusion criterion in 12 clinical trials for malignant solid tumor, of which 10 are open and 2 are closed. Of the trials that contain BRAF V600E and malignant solid tumor as inclusion criteria, 6 are phase 1 (4 open), 1 is phase 1/phase 2 (1 open), and 5 are phase 2 (5 open) [ 5 ] Flubendazole (FLU) and fenbendazole (FEN) belong to benzimidazolesā€”pharmaceuticals widely used in veterinary and human medicine for the treatment of intestinal parasites as well as for the treatment of systemic worm infections. In recent years, usage of these drugs increased, which resulted in a larger contamination of the environment and possible negative effects on biota

Fenbendazole: Has anyone tried - Advanced Prostate

A new study suggests that a person's risk of progressing from a benign condition called monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma, a type of blood cancer, can change over time.. On average, about 1% of people with MGUS go on to develop multiple myeloma each year. Doctors typically estimate a person's risk of progressing soon after MGUS is diagnosed. April 19 -- Back in the 1970s, Dr. Steve Rosenberg invented a new field of cancer treatment: immunotherapy, the harnessing of the body's own immune system to.. Dendritic cells possess the ability to activate specific memory cells that recognize antigens in the tumor, these antigens have to be previously presented to them, by the dendritic cells. With this information, dendritic cells then instruct the body to fight against certain kinds of antigens and recognize specific markers of the cancer P.O. Box 3001 Homer, AK 99603. Suggested donation is $125. NeuroModulation Technique or NMT is an excellent healing technique that eliminates malfunctions caused by emotions, stress, thoughts and even accidents that may have led to the development of your cancer. www.nmt.md gives more information

A De-Wormer for Cancer :: Longevity Medica

The term cancer encompasses more than 100 different forms of cancer, most of which are named for the organ or cell type with which they start. The main categories of cancer include carcinoma, sarcoma, leukemia, lymphoma or myeloma, and central nervous system cancers The Cancer Support Community has added 3 new educational resources to the Frankly Speaking About Cancer: Clinical Trials library. The materials highlight the importance of diversity in clinical trials and provide information for patients to determine if a clinical trial is right for them. Read June 17, 2021 Cannabidiol (CBD) is a compound in the cannabis plant that may help ease cancer symptoms and side effects of treatment. Learn more here

Dear Connie, I cannot imagine what you have gone through to lose a husband like that due to a surgery. I am so sorry for that. The connection between the water issues at Camp Lejeune and brain cancer is really a tough one because typically brain cancer comes about as a result of a combination of factors, although exposures to chemicals such as what was in the water at Camp Lejeune is certainly. Vitamin E is an umbrella term for a group of 8 fat soluble antioxidants including alpha-, beta-, gamma-, and delta-tocopherol, and alpha-, beta-, gamma-, and delta-tocotrienol, though alpha. 33. Candrilli S, Bell T, Irish W, et al. A comparison of inpatient length of stay and costs among patients with hematologic malignancies (excluding hodgkin disease) associated with and without acute renal failure. Clin Lymphoma Myeloma. 2008;8:44-51. 34. Givens ML, Crandall J. Renal complications in oncologic patients

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 July 2021), Cerner Multumā„¢ (updated 1 July 2021), ASHP (updated 30 June. Eat more fruits and vegetables. Following a diet that includes lots of fruits and vegetables may help to reduce the size of your prostate. Eat a wide range of fruits and vegetables in a variety of colors, such as red, green, purple, yellow, and orange. Tomatoes may be especially beneficial for reducing the size of your prostate since they contain high levels of lycopene, so make sure to. Live Assistance. NCI Agents can answer your questions about cancer, clinical trials, and quitting smoking. However, they are not health care providers and do not provide medical advice. LiveHelp is not a substitute for talking with a health care professional Lancet 2018; 391: 1023-75). According to the study, the 5-year survival rate for most cancers in Finland is among the highest in the world. In terms of 5-year survival rate, we are the third best country in Europe in treating prostate, breast and adult's brain cancer. For example, 93.2 % of patients with prostate cancer live five years. Leptomeningeal disease may also be referred to as carcinomatous meningitis or neoplastic meningitis. Most often with this complication, people have multiple neurological symptoms including visual changes, speech problems, weakness or numbness of one side of the body, loss of balance, confusion, or seizures

Fenbendazole was predicted to be able to interact with MAP kinase p38 alpha, whose dysregulation was associated with advanced stages and short survival in cancer patients . On the other hand, for mebendazole, presumed interactions with tyrosine-protein kinase ABL and vascular endothelial growth factor receptor 2 were recognized as the most. An Oklahoma man who was once diagnosed with small-cell lung cancer and told hat he only had three months live claims he is now tumor-free thanks to a $5 deworming drug usually meant for dogs. Joe.

Radiation necrosis: Rarely, a mass of dead (necrotic) tissue forms at the site of the tumor. If this occurs, it usually develops months to years after radiation is given. Surgery may be needed to remove the necrotic tissue. Damage to healthy brain tissue: Although rare, this side effect can cause headaches, seizures, or even death Stomach cancer: A less common form of cancer, affecting about 28,000 Americans per year. Testicular cancer: Diagnosed in 1 in 250 men/boys annually per the ASCO. The two main types are non-seminomas (more common, involving numerous cell types) and seminomas. Thyroid cancer: This cancer begins in the thyroid gland, located in the front of the neck Fenbendazole had been administered once 12 months previously with no apparent adverse effects. On presentation to the RVC, the cat was relatively bright but weak. The heart rate was 180 beats/min and a gallop sound was audible. The mucous membranes were very pale, and the cat was icteric. There was some increased upper respiratory tract noise Symptoms of Multiple Myeloma and Lymphoma. ā‡‘ back to top. Symptoms for Hodgkin's and non-Hodgkin's lymphomas include: (vi .202-204) Chronic fatigue. Cough. Difficulty breathing or chest pain. Fever, with or without chills. Increased effects of alcohol. Itching At Memorial Sloan Kettering, we design a treatment strategy specifically tailored for you, based on (but not limited to): the type of non-Hodgkin lymphoma you have and whether it is aggressive (fast growing) or indolent (slow growing) the stage or extent of your disease. the molecular and genetic features of your disease